Showing posts with label Sarms. Show all posts
Showing posts with label Sarms. Show all posts

Thursday, 30 November 2017

Sarm Powders S-23

Sarm Powders S-23

Product Name:S-23
Chemical Name:(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
CAS NO.:1010396-29-8
Molecular Formula:C18H13ClF4N2O3
Molecular Weight:416.753 g/mol
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.

Developed by GTx, S-23 is an orally active nonsteroidal SARM with a very high binding affinity to androgen receptors. This makes it stronger than other popular SARMS like Ostabolic (mk-2866) or Andarine (S-4). Therefore, the main effects of S-23 are increased muscle mass, decreased fat mass, and a decrease in the size of the prostate.

Dosages and Cycles

Dosages of S-23 can vary, and they will be very dependent on what the goal is. For instance, if a user were looking for muscle building and fat loss, a dose of 15-25 mgs per day would be appropriate. On the other hand, if someone was looking to use it for the contraceptive effects, a higher dose of around 50 mgs per day would be more effective.

Wednesday, 29 November 2017

Sarm Powders Testolone RAD140

Sarm Powders Testolone RAD140

Product Name:Testolone,RAD-140
CAS NO.:1182367-47-0
Molecular Formula:C20H16ClN5O2
Molecular Weight:393.83
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

RAD140(Testolone) is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting,it has similar effects to those of anabolic steroids, but without the harsh side effects because it acts on the androgen receptors in a selective manner.

Who need Testolone (RAD140)

1.Those who have low testosterone because of health issues, or prior abuse of anabolic steroids. 
2.Bodybuilders who want to bridge between steroid cycles. Imagine being able to use testosterone in between your existing anabolic steroid cycles without worrying about suppression and damaging your HPTA. This will allow you to keep more strength and muscle off cycle then you ever have before. 
3.Those who want to use a performance enhancing drug, but are concerned with the possible side effects. In such situation, one could cycle RAD140 instead of anabolic steroids and not worry about shutdown or the negative health effects caused by steroids. 
4.Those sensitive to gynecomastia. RAD140 is like using testosterone, but without the risk of estrogenic side effects because it does not aromatize into estrogen. Therefore, if a testosterone base is needed during a cycle, RAD140 can be used without fear of getting bitch tits or bloating. 

Benefits of RAD140

Akin to having an anabolic steroid and prohormone cycle, you’re going to have the following benefits when you use RAD 140 SARM:

1.Enhanced speed, stamina and endurance during high-intensity workouts
2.Faster buildup of muscular tissues that helps you achieve more gains in a shorter period of time
3.Based on medical tests, RAD 140 SARM also displayed a greater anabolic effect than testosterone when used. Researchers pointed out that besides having a more “reinforced” effect than testosterone, RAD 140 SARM was also seen to help reduce the androgenic side effects that can be potentially caused by the same on the prostate.

This makes its usage way safer and more effective compared to traditional prohormones and anabolic steroids available commercially.

Dosage

RAD140 can be dosed at 20-30 milligrams (mg) per day, and thanks to a relatively long half life, you can get away with only once a day dosing schedule. Regarding the possible cycle durations, RAD140’s length of use can vary from 6 to 12 weeks. Since it usually comes in liquid form, this SARM is squirted into the mouth, swallowed, and chased down with juice. There is no need to let it sit in the mouth or under tongue; in fact, sublingual use is highly discouraged.

Sarm Powders Stenabolic SR9009

Sarm Powders Stenabolic SR9009

Product Name:SR9009
CAS NO.:1379686-30-2
Molecular Formula:C20H24ClN3O4S
Molecular Weight:437.94026
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

























In spite of being associated with SARMS, Stenabolic (SR9009) is in fact a Rev-ErbA ligand.  It means SR binds to this protein and makes it more active.  As a result, the user will experience a lot of positive effects, such as increased fat loss, enhanced endurance, and many other health benefits.

As mentioned beforehand, SR9009 is a synthetic Rev-Erb ligand, which is taken orally. This is a very unique compound.  By stimulating the Rev-Erb protein, SR9009 has the ability to greatly influence a lot of regulatory mechanisms in the human body.  For instance, it can affect the circadian rhythms, lipid and glucose metabolism, fat-storing cells, as well as macrophages.  Hence, Stenabolic will allow the user to lose fat and drastically increase endurance, both of which are very desirable effects for an athlete.

Uses in bodybuilding

There is no need to be a genius to realize all the possibilities SR9009 opens to an athlete - amazing endurance and strength, fat loss, muscle hypertrophy (growth), improved cholesterol and blood sugar levels, and an increased metabolism.  Hence, one can expect results similar to those seen with Cardarine (GW-501516), but with considerably more extra benefits.  Besides, since stenabolic works great both solo or stacked, it will be a very good addition to any steroid or SARMS cycle, and it will give especially impressive results when used together with Cardarine.

All in all, Stenabolic will allow you to do more cardio training, lift more, lose fat, gain lean muscle mass, and improve cholesterol levels.  Cholesterol and cardio management is very important when using SR in combination with such steroids as Anavar or Trenbolone.

Medical uses

Logically, with so many positive effects, SR9009 will have an extremely varied use in medicine.  For instance, the drastic decrease in triglycerides and plasma glucose will be a huge help in the treatment of type 2 diabetes.  What’s more, Stenabolic will be a crucial element in the treatment of sarcopenia - muscle and strength loss caused by aging.

Additionally, SR9009 will allow doctors to treat obesity in those who for medical reasons cannot train or carry out any exercises, as it can replace exercise.  Finally, it is very hard to overestimate its effectiveness in the treatment of cholesterol related conditions or metabolic syndromes.

Recommended dosages

The optimal dosages range from 20 to 30 milligrams (mgs) per day.  However, there is one drawback - due to a very short half life, you will need to space it out throughout the day for the best balance of the active substance in the body.  Thus, it is best to use stenabolic every 2-4 hours, depending on the exact dosage used.  For example, when the daily dosage is 30 mgs, you can take 10 mgs every 4 hours.

Sarm Powders Anabolicum/LGD-4033

Sarm Powders Anabolicum/LGD-4033

Product Name:LGD-4033
Alias:VK5211,Anabolicum
CAS NO.:1165910-22-4
Molecular Formula:C14H12F6N2O
Molecular Weight:338.25
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

























What is LGD-4033

Anablicum (LGD-4033) is a selective androgen receptor modulator (SARM), discovered by Ligand Pharmaceuticals Inc and perfected by SARMS1. LGD-4033 binds to the androgen receptor of muscle and bone selectively, exhibiting similar effects as testosterone, with only partial agonist activity on the prostate. It was developed as a way to treat diseases or conditions associated with muscle and bone deterioration. The advantage a SARM like LGD has over testosterone is the difference in activity it has on the body outside of muscle and bone.

Anabolicum (LGD-4033) is unarguably the strongest SARM on the market today as far as anabolic power. It adds extra muscle building power to a cutting cycle, strength and size to a bulking cycle, and resilience for the endurance athlete. Used by itself or stacked with one or more other compounds, LGD demands recognition in the world of health, fitness, and bodybuilding.

How it works

LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds to the androgen receptor with high affinity and selectivity. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands. LGD-4033 has recently completed a Phase I Multiple Ascending Dose study in healthy volunteers.  This randomized, double-blind, placebo-controlled Phase I study established the safety and tolerability up to doses of 22 mg per day.

LGD-4033 Benefits

Anabolicum (LGD), like other popular SARMS, is very versatile and has a list of benefits no matter the goal of the user. Whether it’s lean muscle mass, maintenance of your hard earned gains during a cutting cycle, or bridging the gap between steroid cycles, LGD-4033 can be a very beneficial tool. Studies suggest that this SARM will lend therapeutic benefit to many testosterone deficiency conditions. In fact, it’s not unheard of to hear of improvements in joint pain or nagging injuries after starting a course of Anabolicum (LGD), much like its cousin Ostarine (MK-2866). In addition, LGD can increase strength, vascularity, and fat loss while bulking, and it can help during “recomposition” (recomp).

Doses and Half-life

Anabolicum (LGD) is most commonly recommended at 5-10mg per day with once daily dosing schedule. The half-life of LGD is between 24-36hrs. It has been found to be well tolerated at up to 22mg/day in people.

Sarm Powders Andarine/S-4

Sarm Powders Andarine/S-4

Product Name:Andarine,S-4
Alias:GTX-007
CAS NO.:401900-40-1
Molecular Formula:C19H18F3N3O6
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

























Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,using the non-steroidal androgen antagonist bicalutamide as a lead compound.

Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH

S-4 belongs to a class of chemicals known as SARMS or selective androgen receptor modulators. Like typical androgens, SARMS bind to the androgen receptor however SARMS create selective anabolic activity.Compared to testosterone and other anabolic steroids and pro hormones, the advantage of SARMS such as S-4 is that they do not have androgenic activity in non-skeletal-muscle tissues.

Losing Bodyfat (Cutting)

Certain steroids are considered “cutting” steroids such as Winstrol and Anavar. These steroids don’t offer too much in large gains in muscle mass but are very effective in leaning out the body. The SARM S-4 has very similar properties.As S-4 shows this binding affinity to the AR, it demonstrates the similar fat burning effects. S-4 also shows a decrease in LPL (lipoprotein lipase) which is an enzyme that causes lipid accumulation.

S-4 also fits into a cutting protocol for the concurrent reduction in body fat with maintenance of muscle mass in a hypocaloric environment.
As S4 has both anabolic and androgenic effects in muscle tissue, it will not only help with fat loss, but maintain and even increase muscle mass when cutting.S-4 causes increases in vascularity and promote a very nice, “quality”, hard look to the users muscles, with little or no water retention.

In this way S-4 can be compared to Winstrol, without the harsh hair loss or extreme adverse effects on cholesterol.

Also other popular steroids/Prohormones used for cutting such as winstrol or epistane can have a notable effect on drying out of the joints. S-4 doesn’t suffer such consequences so the athlete is still able to lift heavy in order to maintain/increase muscle mass and strength.

Another advantage S-4 offers for cutting is that it doesn’t give the painful pumps associated with other popular steroids/Prohormones. Back and calf pumps are particularly detrimental for cutting as it limits the ability to perform cardio.

Strength gains and Lean mass Gains

Due to its androgenicity in muscle tissue, S-4 is a good agent for increases in strength without bloat and large increases in weight.Dosing at 50mg+ is the sweet spot for such gains.

Also, like the oral steroid Anavar (Var) weight gain with S4 may not be that great in comparison to bulking steroids such as deca or Superdrol, but what the lean mass and strength gained during the cycle is kept and not lost after the cycle.

With all dosing protocols, as the half life of S-4 is 4 hours, splitting up the dose into multiple applications is advised.

Sarm Powders YK11/YK-11

Sarm Powders YK11/YK-11

Product Name:YK11
CAS NO.:431579-34-9,1370003-76-1
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

























YK11 Benefits

SARM YK-11 is one of the most powerful S.A.R.M.S (Selective Androgen Receptor Modulator) on the market today. It is used to achieve Anabolic Steroid type results, but without the negative side effects and legality issues.This particular SARM “YK-11” is for helping the user Gain Lean Muscle Tissue and Lose Fat simultaneously.  

YK11 will have similar affects to DHT (possibly more potent) without the negatives of DHT. What this means is that the product will most likely be suppressive and require a post cycle, but not cycle support. It also won't have androgenic side affects like hair loss, acne, etc. The increase in follistatin caused by YK11 will act as an antagonist to mystatin (it will block myostatin) as well as the anabolic growth properties of YK11.

YK11 shows a lot of promise as an apt anabolic SARM. With the muscle growth potential it brings, it’s as effective as anabolic steroids and prohormones without the unwanted side effects connected to the latter.SARM YK-11 is a powerful SARM supplement promoting massive lean muscle gains which is a great benefit for those wanting to have an aesthetic and shredded physique!

How it works?

In direct comparison to to LGD-4033 as the reference for assay upon animal models of anabolism and androgenicity, YK-11 demonstrated higher efficacy withing anabolic parameters and lesser androgenicity at equivalent dosages.

It induces muscle cells to make more follistatin which is a strong myostatin inhibitor. Myostatin (also known as growth differentiation factor 8, is a myokine (protein) produced by muscle cells that acts on muscle cells to inhibit myogenesis. Myogenesis is muscle cell growth and differentiation. Research through the years show that when you block myostatin, it allows for significantly more muscle mass. So in research myostatin inhibitors are researched to find cures for muscle diseases.

We expect YK11 to be more potent than SARM LGD in terms of overall growth and feel. At this time, we expect this to be the strongest SARM on the market at a regular dosing. While suppression can occur, we expect this product to have low androgenic properties and can be used by both men and women. From our experience with SARMs, we find there are less losses of on-cycle results than pro-hormones, although typically not as potent. We do expect this product to have similar results as a moderately dosed Halodrol, without the alpha-male/androgenic feelings while on it.

Dosages and Suggestion

Recommended maximum dose YK11 is require dosages of 2.0-5.0mg b.i.d. in males and 0.5mg-2mg b.i.d. in females to achieve optimal effects in humans for the noted indications.

Sarm Powders Ibutamoren/MK-677

Sarm Powders Ibutamoren/MK-677

Product Name:Ibutamoren,MK-677
Alias:MK-0677,L-163191,Nutrobal
CAS NO.:159634-47-6
Molecular Formula:C27H36N4O5S
Molecular Weight:528.664
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

























Ibutamoren (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue,mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,and human studies have shown it to increase both muscle mass and bone mineral density,making it a promising therapy for the treatment of frailty in the elderly.It also alters metabolism of body fat and so may have application in the treatment of obesity.

How it Work

Nutrobal works by increasing the release of several hormones in the body, including growth hormone and IGF-1, and it does this without affecting cortisol levels. Subsequently, the increase in IGF-1 and growth hormone comes with a host of benefits which we will discuss in this article. Furthermore, it fights also obesity by altering the metabolism of body fat.

Athletic Use

Nutrobal will cause a rise in IGF-1 and growth hormone even in a diet induced nitrogen wasting state. This means that even without making any serious effort in the kitchen or the gym it is almost impossible not to gain muscle mass and lose body fat with nutrobal. Therefore, athletes can benefit in several ways from Nutrobal:
1. Fat loss
2. Muscle gain
3. Injury healing and bone strengthening

Moreover, it will also aid in such things as endurance, mood, sleep, and general health. Hence, nutrobal Mk-677 gives the athletes all the benefits of growth hormone and IGF-1 increase without the high financial cost and side effects of the HGH.

Ibutamoren Stacking

1. Endurance: Many endurance athletes have been pinched over the years for human growth hormone, so naturally, we can deduce that nutrobal would work beautifully for this purpose. Stack it with 20 milligrams (mg) a day of cardarine for a lethal endurance stack, and blow away your competition on your next bicycle/road race.

2. Fat loss: Nutrobal is so good at preventing fat gain and fighting obesity, that it is almost impossible to gain body fat on it. However, you can take these effects even further - stack it with andarine and cardarine to get a lethal fat burning triple stack.

3. Mass gain: Being able to gain mass without the fear of spiking your body fat measurement is something we all wish for, but unless you have tremendous genetics, it is very difficult to accomplish. Nutrobal evens the playing field when stacked with LGD and anabolic steroids.

4. Overall health: Nutrobal can give an improved mood, sleep, cholesterol levels, injury healing, and immune system boosting. Stack it with N2guard, Ostarine and HCGenerate ES to get a perfect stack for those who have let their bodies go due to injury, or who are in between cycles and looking to improve their overall health without risking anabolic steroid use and having a setback.

Ibutamoren Dosage

Just like with other SARMs, the half life of nutrobal is a robust 24 hours, so once a day dosing is all that is needed. 
It is recommended taking nutrobal upon waking up, on an empty stomach before you eat breakfast, and 25 milligrams (mg) a day is the bread and butter dosage. Some users will go as low as 5mg, or as high as 50mg.

Sarm Powders Endurobol Cardarine/GW501516

Sarm Powders Endurobol Cardarine/GW501516

Product Name:Endurobol,GW501516,Cardarine
Alias:GSK-516,GW-501516
CAS NO.:317318-70-0
Molecular Formula:C21H18F3NO3S2
Molecular Weight:453.50
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade


GW501516 (also known as GW-501,516, GW1516, GSK-516 and Endurobol)is a PPAR receptor. It activates the same pathways activated through exercise, including PPAR and AMP-activated protein kinase. It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone.

Medical Use

Cardarine was primarily developed to treat obesity, diabetes, lipid strain, and heart health problems. As a matter of fact, those who run blood work will notice that cardarine will magically aid with lipid strain, and their cholesterol levels will improve substantially.

Athletic Use

Endurance athletes may increase exercise endurance by stacking this PPAR with the AMP analog drug AICAR, or run cardarine solo. As a result, they will have a greater ability to reach higher RPM’s during their runs without hitting the maximum heart rate. Regarding the bodybuilders, cardarine can benefit them in two ways:
1. Its ability to burn fat
2. Its ability to help the athlete have harder and longer workouts, without getting winded.

Fat Loss

In terms of obesity, cardarine reverses metabolic abnormalities in obese and pre-diabetic men by stimulating fatty acid oxidation. That is, it burns fat by increasing glucose uptake in skeletal muscle tissue, which changes the body’s metabolism to burn fat for energy instead of muscle or carbs. Incredibly, it does all this without dropping blood sugar levels like diabetic drugs do. Interestingly, when mice were given a high fat diet, they still lost fat, which proves that cardarine prevents obesity.

Cardarine Stacking

1. Endurance: It is recommended stacking cardarine with AICAR and/or Equipoise. This is the ultimate endurance stack that will turn you into a race horse.

2. Fat loss: The best shredder stack would be stacking cardarine with S4 (Andarine). This is a well known potent ‘cutting’ stack.

3. Anabolic steroid stack: If you run moderate doses of anabolic steroids, or you run any harsh compound like trenbolone, then cardarine will aid in not only your lipids, but also with your ability to ‘catch your wind.’ Therefore, cardarine is a perfect stack for trenbolone, which makes many athletes lose their breath fast.

4. During PCT (post cycle therapy) or bridge: Since cardarine is not hormonal, it is in no way suppressive. Hence, you should not be scared of using it to keep fat off and improve your workouts between cycles during your bridge and PCT.

5. SARMs triple stack: If you want aato recomp, cardarine stacks beautifully with S4 and MK-2866.

Cardarine Dosage

The half life of cardarine is 20-24 hours. This means that once a day dose is totally fine. Some athletes like to use all the 20 mg an hour before their workout session, and others will split the dose in half in the AM and PM.

Sarm Powders MK-2866/Ostarine

Sarm Powders MK-2866/Ostarine

Product Name:Ostarine,Enobosarm
Alias:GTx-024,MK-2866
CAS NO.:841205-47-8
Molecular Formula:C19H14F3N3O3
Molecular Weight:389.3279696
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade


SARM

Ostarine is selective androgen receptor modulator(SARM) and a kind of white powder.Ostarine belongs to chemical raw material. It is also known as enobosarm. Ostarine (MK-2866) is a SARM developed by GTx for the prevention and treatment of muscle wasting. It may eventually be a medical prescription for the prevention of cachexia, atrophy and sarcopenia as well as for Hormone or Testosterone Replacement Therapy.

As a research chemical, Ostarine belongs to a class of chemicals know as SARMS or selective androgen receptor modulators. SARMS create selective anabolic activity at certain androgen receptors. In comparison to testosterone and other anabolic steroids, the advantage of SARMS, is they do not have androgenic activity in non-skeletal muscle tissues. Ostarine is effective in maintaining and increasing lean body mass.

Enobosarm (Ostarine, MK-2866, GTx-024) - affects both muscle and bone, intended mainly for osteoporosis but also general treatment for andropause and reversing muscle sarcopenia in the elderly and for cachexia in cancer patients.Nonsteroidal selective androgen receptor modulator (SARM) used in the treatment of osteoporosis and muscle wasting in animal models. A potential compound for the treatment of hypoactive sexual desire disorder.

Ostarine Use

Increasing lean mass gains
Enhancement for  strength
Bodybuiling exercise
Joint healing abilities
Hormone Anabolic raw material (even at doses as low as 3 mg)

For bodybuilding

Ostarine is the most anabolic of any SARMS, making its first and foremost use for wanting to gain lean muscle. The gains in total weight will not be comparable to bulking steroids, however the total gains will almost entirely be lean muscle.

For cutting

Ostarine would primarily fit into a cutting protocol for the maintenance of muscle mass while reducing calories. One of the most disheartening outcomes of cutting is the loss hard earned muscle mass. The drop in metabolic rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic environment for loss of muscle tissue. As Ostarine has anabolic effects, the dieter can cut calories without having to worry about muscle or strength loss. Ostarine has also shown noticeable nutrient partitioning effects among users, another reason why it can be of great help when cutting.

For Recomping

Where Ostarine shines for recomping is in its nutrient partitioning benefits. Calories are taken from fat stores and calorie intake is fed to the muscle tissue. In fact many users report that Ostarine consumed at maintenance calories produces weight loss, while still getting increases in strength and muscle mass.

Ostarine shines in recomping due to its nutrient portioning results. Calorie is used to build muscle which helps in weight loss and enhancing muscle mass and strength. Suggested dosing is 12.5-25 mg for 4-8 weeks.