Sarm Powders S-23

Sarm Powders S-23

Product Name:S-23
Chemical Name:(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
CAS NO.:1010396-29-8
Molecular Formula:C18H13ClF4N2O3
Molecular Weight:416.753 g/mol
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.

Developed by GTx, S-23 is an orally active nonsteroidal SARM with a very high binding affinity to androgen receptors. This makes it stronger than other popular SARMS like Ostabolic (mk-2866) or Andarine (S-4). Therefore, the main effects of S-23 are increased muscle mass, decreased fat mass, and a decrease in the size of the prostate.

Dosages and Cycles

Dosages of S-23 can vary, and they will be very dependent on what the goal is. For instance, if a user were looking for muscle building and fat loss, a dose of 15-25 mgs per day would be appropriate. On the other hand, if someone was looking to use it for the contraceptive effects, a higher dose of around 50 mgs per day would be more effective.

Sarm Powders SR9011

Sarm Powders SR9011 

Product Name:SR9011
CAS NO.:1379686-29-9
Molecular Formula:C23H31ClN4O3S
Molecular Weight:479.03524
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.

The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

Sarm Powders Andarine/S-4

Sarm Powders Andarine/S-4

Product Name:Andarine,S-4
Alias:GTX-007
CAS NO.:401900-40-1
Molecular Formula:C19H18F3N3O6
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,using the non-steroidal androgen antagonist bicalutamide as a lead compound.

Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH

S-4 belongs to a class of chemicals known as SARMS or selective androgen receptor modulators. Like typical androgens, SARMS bind to the androgen receptor however SARMS create selective anabolic activity.Compared to testosterone and other anabolic steroids and pro hormones, the advantage of SARMS such as S-4 is that they do not have androgenic activity in non-skeletal-muscle tissues.

Losing Bodyfat (Cutting)

Certain steroids are considered “cutting” steroids such as Winstrol and Anavar. These steroids don’t offer too much in large gains in muscle mass but are very effective in leaning out the body. The SARM S-4 has very similar properties.As S-4 shows this binding affinity to the AR, it demonstrates the similar fat burning effects. S-4 also shows a decrease in LPL (lipoprotein lipase) which is an enzyme that causes lipid accumulation.

S-4 also fits into a cutting protocol for the concurrent reduction in body fat with maintenance of muscle mass in a hypocaloric environment.
As S4 has both anabolic and androgenic effects in muscle tissue, it will not only help with fat loss, but maintain and even increase muscle mass when cutting.S-4 causes increases in vascularity and promote a very nice, “quality”, hard look to the users muscles, with little or no water retention.

In this way S-4 can be compared to Winstrol, without the harsh hair loss or extreme adverse effects on cholesterol.

Also other popular steroids/Prohormones used for cutting such as winstrol or epistane can have a notable effect on drying out of the joints. S-4 doesn’t suffer such consequences so the athlete is still able to lift heavy in order to maintain/increase muscle mass and strength.

Another advantage S-4 offers for cutting is that it doesn’t give the painful pumps associated with other popular steroids/Prohormones. Back and calf pumps are particularly detrimental for cutting as it limits the ability to perform cardio.

Strength gains and Lean mass Gains

Due to its androgenicity in muscle tissue, S-4 is a good agent for increases in strength without bloat and large increases in weight.Dosing at 50mg+ is the sweet spot for such gains.

Also, like the oral steroid Anavar (Var) weight gain with S4 may not be that great in comparison to bulking steroids such as deca or Superdrol, but what the lean mass and strength gained during the cycle is kept and not lost after the cycle.

With all dosing protocols, as the half life of S-4 is 4 hours, splitting up the dose into multiple applications is advised.

Sarm Powders Ibutamoren/MK-677

Sarm Powders Ibutamoren/MK-677

Product Name:Ibutamoren,MK-677
Alias:MK-0677,L-163191,Nutrobal
CAS NO.:159634-47-6
Molecular Formula:C27H36N4O5S
Molecular Weight:528.664
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

Ibutamoren (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue,mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,and human studies have shown it to increase both muscle mass and bone mineral density,making it a promising therapy for the treatment of frailty in the elderly.It also alters metabolism of body fat and so may have application in the treatment of obesity.

How it Work

Nutrobal works by increasing the release of several hormones in the body, including growth hormone and IGF-1, and it does this without affecting cortisol levels. Subsequently, the increase in IGF-1 and growth hormone comes with a host of benefits which we will discuss in this article. Furthermore, it fights also obesity by altering the metabolism of body fat.

Athletic Use

Nutrobal will cause a rise in IGF-1 and growth hormone even in a diet induced nitrogen wasting state. This means that even without making any serious effort in the kitchen or the gym it is almost impossible not to gain muscle mass and lose body fat with nutrobal. Therefore, athletes can benefit in several ways from Nutrobal:
1. Fat loss
2. Muscle gain
3. Injury healing and bone strengthening

Moreover, it will also aid in such things as endurance, mood, sleep, and general health. Hence, nutrobal Mk-677 gives the athletes all the benefits of growth hormone and IGF-1 increase without the high financial cost and side effects of the HGH.

Ibutamoren Stacking

1. Endurance: Many endurance athletes have been pinched over the years for human growth hormone, so naturally, we can deduce that nutrobal would work beautifully for this purpose. Stack it with 20 milligrams (mg) a day of cardarine for a lethal endurance stack, and blow away your competition on your next bicycle/road race.

2. Fat loss: Nutrobal is so good at preventing fat gain and fighting obesity, that it is almost impossible to gain body fat on it. However, you can take these effects even further - stack it with andarine and cardarine to get a lethal fat burning triple stack.

3. Mass gain: Being able to gain mass without the fear of spiking your body fat measurement is something we all wish for, but unless you have tremendous genetics, it is very difficult to accomplish. Nutrobal evens the playing field when stacked with LGD and anabolic steroids.

4. Overall health: Nutrobal can give an improved mood, sleep, cholesterol levels, injury healing, and immune system boosting. Stack it with N2guard, Ostarine and HCGenerate ES to get a perfect stack for those who have let their bodies go due to injury, or who are in between cycles and looking to improve their overall health without risking anabolic steroid use and having a setback.

Ibutamoren Dosage

Just like with other SARMs, the half life of nutrobal is a robust 24 hours, so once a day dosing is all that is needed. 
It is recommended taking nutrobal upon waking up, on an empty stomach before you eat breakfast, and 25 milligrams (mg) a day is the bread and butter dosage. Some users will go as low as 5mg, or as high as 50mg.